Lifeline Scientific, Inc.

Eli Lilly and Company

Gyrus Ent L.l.c.

Organ Recovery Systems, Inc.

Gilmour, Inc.

Other

Andrew Burroughs

Dickon Isaacs

John Brassil

David C Kravitz

Kelvin G M Brockbank

Douglas A Schein

Donald R Owen

Benjamin Rush

Rodney Hal Monson

Jacob Schieffelin Brauer

Phillip Andrew Ryan

Constance Elaine Johnston

Richard T Fraser

Perry Robin Mykleby

Tasos George Karahalios

Stanley Harris

Carrie Deanne Mills

Energy Cruse, Ii

Scott Andrew Brenneman

Thomas Franz Enders

Eric Christopher Sugalski

James Gerard Tappel

Benjamin Mark Chow

Dennis J Steibel

Dave Hixson

Andrew Hodge

Jeremiah P O'Leary

Martin Thaler

Douglas J Burnworth

Thomas C Oyler

Dennis Steibel, Jr

Timothy S DeVore

Douglas Shaulis

Volker Roos

Mark James Fisher

Shu Kun Chang

Kenneth Alan Ritsher

Peter Ehling

David Hixson

David R Little

Richard A Maurer

Christopher G Curtis

Anthony Lawrence Schaff, Sr

Traci Jo Barron

Denis S Maurer

Anastasios G Karahalios

Richard Charles Thorne

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

Apparatus and method for maintaining and/or restoring viability of organs

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

A powered surgical apparatus can be used with a source of irrigation fluid and a source of suction. The powered surgical apparatus can include a cutting blade assembly and a handle. The handle can include an upper portion defining a distal section connectable to the cutting blade assembly and a lower portion extending downwardly from the upper portion. The handle can be connectable to the source of irrigation fluid and the source of suction. The system can also include a manually actuable input device that provides at least one signal relevant to at least one operation of the system, and a controller that receives the at least one input signal and provides an output signal to perform the at least one operation of the system.

Powered surgical apparatus, method of manufacturing powered surgical apparatus, and method of using powered surgical apparatus

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

Method for controlling perfusion of an organ

Method of determining transport and/or storage parameters for maintaining viability of an organ

A medication and needle module () for an injection device. The module () includes a housing () including a first portion () and a second portion () detachably connected together, the second housing portion having a periphery complementarily shaped with a cavity () in the injection device () to be loadable therein, a primary container () within the first housing portion and including a medication filled reservoir (), a secondary container () within the second housing portion and including a medication tillable reservoir, a needle cassette () rotatably mounted within the second housing portion and including a plurality of delivery needles (), and a transfer needle assembly () within the housing. The detachability of the second housing portion from the first housing portion permits the second housing portion with the secondary container and the needle cassette to be loaded as a unit independently of the first housing portion into the injection device cavity for use.

Module for a medication injection device

An apparatus for delivering a pharmaceutical liquid to a patient includes an outer casing; a needle cassette housed in the casing and containing a plurality of mutually parallel drug injection needles; a drug cartridge housed in the casing, containing a liquid and including a sealable aperture for accessing the liquid; a direct drive assembly housed in the casing and engageable with the drug cartridge to expel a measured dose of the liquid through the aperture; a lifter assembly housed in the casing and engageable with the needle cassette to drive one of the plurality of needles partially out of the casing and into a patient while also accessing the liquid in the drug cartridge through the scalable aperture, and thereafter to withdraw the needle from the patient while halting access of the liquid through the sealable aperture after the measured dose of the liquid has been administered through the needle; motor means in the casing for driving the direct drive assembly and the lifter assembly; computer means for activating the direct drive assembly and the lifter assembly; and a control panel for enabling a user to activate the apparatus.

Injection apparatus having a needle cassette for delivering a pharmaceutical liquid

A guide and follower cooperate to promote a user moving the driver relative to the housing along a travel path that operates the apparatus. The cooperating elements of the nut and the driver are disengaged when the driver is disposed in a reset segment of the travel path, and the cooperating elements of the nut and the driver become engaged when the driver is shifted through a nut engaging segment of the travel path from the reset segment to a nut rotating segment of the travel path. The engagement of the cooperating elements of the nut and the driver cause the nut to screw proximally along the threaded shaft of the drive member when the driver is shifted through the nut rotating segment from the nut engaging segment to an injecting section of the travel path. When the driver is shifted through the injecting section from the nut rotating segment to the reset segment, the nut and the drive member are shifted in the distal direction to axially advance a fluid container piston to dispense medicine, and the cooperating elements of the nut and the driver become disengaged.

Fixed dose medication dispensing device

Growing community of inventors

Kenosha, WI, United States of America

Andrew Burroughs