Glaxo Group Limited

Andrew Bruce Brown

Michael Mary Van Oort

A dry powder pharmaceutical composition comprising (i) a medicament particle fraction comprising medicament particles with an aerodynamic diameter no greater than 10 &#x3bc;m; and (ii) at least 50% of a non-respirable excipient fraction comprising low density excipient particles with an aerodynamic diameter greater than 10 &#x3bc;m and a geometric diameter greater than 30 &#x3bc;m. In additional embodiments of the invention, the pharmaceutical composition includes a respirable excipient fraction comprising excipient particles with an aerodynamic diameter no greater than 10 &#x3bc;m. In a preferred embodiment of the invention, the non-respirable excipient particles include pores adapted to receive a portion of the respirable excipient fraction and/or the medicament fraction.

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Durham, NC, United States of America

Andrew Bruce Brown