Astrazeneca Ab

Astra Zeneca U.k. Limited

Andrew Baxter

Thomas McInally

Nicholas David Kindon

Bryan Glyn Roberts

Michael P Mortimore

Stephen Thom

Stephen Brough

David Cladingboel

Michael Stocks

Timothy Johnson

Roger Victor Bonnert

Alan Wellington Faull

Brian Springthorpe

Craig Johnstone

Matthew Wd Perry

Paul Andrew Willis

Nafizal Hossain

Garry Pairaudeau

Austen Pimm

Richard Evans

Svetlana Ivanova

Nicholas Tomkinson

Fraser Hunt

Marguerite Mensonides-Harsema

John Steele

Elizabeth Kinchin

James Reuberson

Nicholas Kindor

David Harden

David Marriott

Rupert Austin

The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma. 

N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases

The invention provides compounds of formula (I) wherein m, R, n, R, q, X, Y, Z, t, R, R, R, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. 

Compounds

The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma 

The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R, Rand X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Substituted Thiophene compounds

The invention provides compounds of general formulawherein R, m, Q, T, n, R, R, V, W, X and Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention provides compounds of formula (I) wherein R, R, R, R, Z, Q, m, n, X, X, X, Xand T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions

Substituted piperidine compounds useful as modulators of chemokine receptor activity

The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R and R are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.

P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular disease

The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention provides compounds of general formula (I) wherein: R represents optionally substituted, C -C alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH , C -C alkylene or C -C alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C -C alkylene, T may additionally represent NH; n is 1-4; each R and R independently represents H or C -C alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO , NH or N(C -C alkyl), provided that when W represents N, then X represents either C(O) or SO and when W represents CH, then X is other than SO ; R represents optionally substituted phenyl; R and R each independently represent H, C -C alkyl or hydroxyC -C alkyl, or R and R together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R and R each independently represent H or C -C alkyl; and R represents OH or &mdash;NR R ; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.

Growing community of inventors

Loughborough, United Kingdom

Andrew Baxter