Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gmbh

Merck Patent Gellschaft MIT Beschrankter

Andrew Barber

Christoph Seyfried

Gerd Bartoszyk

Rudolf Gottschlich

Hartmut Greiner

Karl-August Ackermann

Joachim Leibrock

Peter Raddatz

Helmut Prucher

Frank Mauler

Henning Boettcher

Steffen Neuenfeld

Inge Stein

Wolf-Dietrich Weber

Hans-Peter Wolf

Helmut Pr&uuml;cher

Klaus Beschmann

Helmut Pruecher

Holger Beeres

Manfred Stohrer

Joseph Maria Martinez

1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists

The invention relates to piperidine derivatives of the formula I

3-Benzylpiperidine

The invention relates to a novel heat-stable form of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diph enylacetamide and to a process for the preparation and isolation of this compound in this novel form and to use for the production of medicaments which contain this compound and/or one of its physiologically acceptable salts.

N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2

Disclosed herein are pharmaceutical preparations which are suitable for the treatment of postoperative ileus and contain at least one compound of the formula I ##STR1## in which R.sup.1 is Ar, cycloalkyl having 3-7 C atoms or cycloalkylalkyl having 4-8 C atoms,

Kappa-opiate agonists effective in the treatment of postoperative ileus

Pharmaceutical preparations which are suitable for the treatment of inflammatory bowel disorders and contain at least one compound of the formula I ##STR1## in which R.sup.1 is Ar, cycloalkyl having 3-7 C atoms or cycloalkylalkyl having 4-8 C atoms,

Kappa-opiate agonists for inflammatory bowel disorders

Novel arylacetamides of the formula I ##STR1## in which Q is R.sup.4 --CH(CH.sub.2 Z)--NA--, ##STR2## R.sup.1 is Ar, cycloalkyl with 3-7 C atoms or C.sub.4 -C.sub.8 -cycloalkyl-C.sub.1 -C.sub.7 -alkyl,

Acrylacetamides

Novel acetamides of the formula I ##STR1## in which Q, R, X and Y have the meanings defined herein, have analgesic and neuroprotective properties and bind with high affinity to kappa receptors.

Acetamides

New analgesic compositions containing a compound of the formula I ##STR1## wherein .dbd.A--B.dbd. is .dbd.CH--CH.dbd. or --N--CR.sup.2 .dbd.,

Analgesic

Growing community of inventors

Weiterstadt, Germany

Andrew Barber