Mayo Foundation for Medical Education and Research

Andrew Badley

Yuan-Ping Pang

Scott H Kaufmann

Gary D Bren

David J Schnepple

Amy M Nguyen

Stacey A R Vlahakis

Haiming Dai

This document provides antibodies against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) short, and more particularly to humanized TRAILshort antibodies that can neutralize TRAILshort. For example, materials and methods for using one or more humanized TRAILshort antibodies to induce apoptosis (e.g., via TRAIL mediated cell death, natural killer (NK) cytotoxicity, and/or CD8+ T cell killing) are provided.

TRAILshort antibody and methods of use

This document provides methods and materials involved in killing HIV infected cells (e.g., CD4 T cells). For example, methods and materials for using one or more Bcl-2 inhibitors (e.g., ABT-199) alone or in combination with one or more agents capable of reactivating HIV (e.g., latency reversing agent) to kill HIV infected cells (e.g., CD4 T cells) are provided.

Method for killing HIV-infected cells using Bcl-2 inhibitors

This document provides methods and materials for treating HIV infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat HIV infections are provided.

Methods and materials for treating human immunodeficiency virus infections

A method of increasing thymic output in an HIV-negative patient, comprising the steps of (a) identifying a HIV-negative patient who is in need of increased thymic output and (b) supplying an effective amount of antiretroviral agent to the patient such that the patient has an increase in na&#xef;ve T-cells.

Method of increasing thymic output in HIV-negative patients by treatment with antiretroviral agents

This document provides to methods and materials related to apoptosis. For example, methods and materials for modulating apoptosis are provided. In addition, methods and materials for treating a mammal having an apoptosis-associated condition are provided.

Growing community of inventors

Rochester, MN, United States of America

Andrew Badley