Pfizer Corporation

Ixchelsis Limited

Evotec Ag

Agrimetis, LLC

Renovis, Inc.

Andrew Antony Calabrese

Alan Daniel Brown

David Ellis

David Hepworth

Koji Ando

Donogh John Roger O'Mahony

Matthew Cox

Satoshi Nagayama

Misato Hirano

Matthew Alexander James Duncton

Mark Ian Lansdell

Maria De Los Angeles Estiarte-Martinez

David Sebastien Fradet

Tadashi Kawashima

Yuji Shishido

Hirotaka Tanaka

Matthew Alexander Duncton

Kentaro Futatsugi

Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include those functionalized on the C-5,6 double bond to provide an aziridine ring system. The method produces spinosyn derivatives that exhibit activity towards insects, arachnids, and nematodes and are useful in the agricultural and animal health markets.

Aziridine spinosyn derivatives and methods of making

The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction. 

Substituted triazole derivatives as oxytocin antagonists

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R, R, R, Rand Rare as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists

The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). 

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Sandwich, United Kingdom

Andrew Antony Calabrese