Aurora Biosciences Corporation

Aurora Discovery, Incorporated

Other

Vertex Pharmaceuticals (san Diego) LLC

Nexus Biosystems, Inc.

Andrew A Pham

Peter J Coassin

Alec Tate Harootunian

Roger Y Tsien

Peter N Pham

Harry Stylli

Minh Vuong

John D Mendlein

Reid Burton Kowallis

Chari Stylli

Michael Lee Kochersperger

Peter J Cassin

The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.

Multi-well platforms, caddies, lids and combinations thereof

The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.

Detector and screening device for ion channels

One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model.

Low fluorescence assay platforms and related methods for drug discovery

The present invention relates to multi-well platforms, lids, caddies and any combination thereof The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.

Multi-well platform

The present invention is relates to an optical fiber assembly which may be used in an optical detection system. The optical fiber assembly may comprise a trifurcated cable and a ball lens in optical communication with the trifurcated cable. The trifurcated cable may comprise an excitation bundle, a first emission bundle for receiving light and a second emission bundle for receiving light.

The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.

Low background multi-well plates for fluorescence measurements of biological and biochemical samples

The invention provides for multi-well plates with greater than 864 wells that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates are particularly well suited for fluorescent measurements.

Growing community of inventors

Del Mar, CA, United States of America

Andrew A Pham