Intel Corporation

Xerox Corporation

Other

Andrew A Berlin

Mineo Yamakawa

Warren Bruce Jackson

David Kalman Biegelsen

Selena Chan

Valluri Ramana Rao

Tae-Woong T Koo

Xing Su

Narayanan Sundararajan

Mark H Yim

Patrick C Cheung

Yuegang Zhang

Qing Ma

Raj B Apte

Li-Peng Wang

Tad H Hogg

Gabi Neubauer

Lars-Erik Swartz

Steven J Kirch

Elmer S Hung

Jaan Noolandi

Feng Zhao

Christopher Marc Gerth

Eric Peeters

Mark T Bohr

Robert Arthur Sprague

Valery M Dubin

Eric Cabot Hannah

Joel A Kubby

Dan A Hays

Meng H Lean

Armin R Volkel

Swaminathan Sivakumar

Eric Saund

Richard H Bruce

Gregory J Kovacs

Philip D Floyd

Gregory B Anderson

Steven B Bolte

Narayan Sundararajan

Horst Haussecker

Lei B Sun

Frederick Joseph Endicott

Patrick C P Cheung

An-Chang Shi

Sunghoon Kwon

Jonathan A Small

G A Neville Connell

James G Chase

Oliver P Guenther

Ken Salsman

Brian Ostrovsky

Bernardo A Huberman

Paul A Koning

Richard O Jones

Todd A Cass

Koenraad F Van Schuylenbergh

Rajeev J Surati

Vineet Gupta

C Michael Garner

Mark B Roth

Bryan M White

Carlos Mochon

Kenneth N Horne

Bjorn R Carlson

Tac-Woong Koo

Steve Kirch

Chee We Ng

Rachel King-Ha Lau

An image acquisition apparatus configured to receive an adjustable image acquisition parameter, wherein said parameter is adjusted based on an image that has had its subject selectively enhanced via comparison with at least one background reference image.

Spatio-temporal differential synthesis ofdetail images for high dynamic range imaging

Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

Biosensor utilizing a resonator having a functionalized surface

In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of known molecular structures to provide a model-based analysis. The estimated parameters may be fused, with further input from physical models of known molecular structures. The fused parameters may be used to characterize the subjects. Such characterization may include the detection and/or identification of specific molecular structures, such as proteins, peptides and/or nucleic acids of known sequence and/or structure. In some embodiments of the invention the structural characterizations may be used to identify previously unknown properties of a subject molecule.

Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures

A micro-fluidic device containing a micro-fluidic inlet channel to convey a process flow, a plurality of micro-fluidic focusing channels to each convey one of a plurality of focusing flows, a focusing manifold coupled with the inlet channel at an inlet port thereof and with the plurality of focusing channels at a plurality of focusing channel ports thereof to focus the process flow by contacting and hydrodynamically impacting at least three sides of the process flow with the focusing flows, and a micro-fluidic outlet channel coupled with the focusing manifold at an outlet channel port to convey the combined focused process flow and focusing flow from the focusing manifold.

Hydrodynamic focusing devices

Provided herein are methods and systems for detecting biomolecular binding events using gigahertz or terahertz radiation. The methods and systems use low-energy spectroscopy to detect biomolecular binding events between molecules in an aqueous solution. The detected biomolecular binding events include, for example, nucleic acid hybridizations, antibody/antigen binding, and receptor/ligand binding.

Methods and systems for detecting biomolecular binding using terahertz radiation

Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the spectroscopy. The chamber may have a resonant cavity to contain a sample for analysis, at least one window to the cavity to transmit the first radiation into the cavity and to transmit a second radiation out, a plurality of reflectors affixed to a housing of the cavity to reflect radiation of a predetermined frequency, the plurality of reflectors separated by a distance that is sufficient to resonate the radiation. The spectroscopic analysis system may be coupled with a nucleic acid sequencing system to receive a single nucleic acid derivative in solution and identify the derivative to sequence the nucleic acid.

Devices and methods for dual excitation Raman spectroscopy

The methods and apparatus, disclosed herein are of use for sequencing and/or identifying proteins, polypeptides and/or peptides. Proteins containing labeled amino acid residues may be synthesized and passed through nanopores. A detector operably coupled to a nanopore may detect labeled amino acid residues as they pass through the nanopore. Distance maps for each type of labeled amino acid residue may be compiled. The distance maps may be used to sequence and/or identify the protein. Apparatus of use for protein sequencing and/or identification is also disclosed herein. In alternative methods, other types of analytes may be analyzed by the same techniques.

Methods and device for analyte characterization

Spectroscopic analysis systems and methods for analyzing samples are disclosed which exploit inelastically scattering radiation to amplify optical signals from an irradiated sample. Samples are irradiated in a chamber having a resonant cavity containing a plurality of affixed reflectors, where selective Stokes scattered radiation is transmitted to a detector for determination of sample identity. Coupling the spectroscopic analysis system and method with a nucleic acid sequencing system is also disclosed for determining nucleic acid sequences.

Stimulated and coherent anti-stokes raman spectroscopic methods for the detection of molecules

An automatic camera steering control for directing video conferences including a communicator with a microphone and a voice activated LED emitter. Cameras receive an LED signal transmitted by the LED emitter and focus on the speaker associated with the activated LED emitter. A controller automatically selects and inserts into the video stream the audio and video of the speaker.

Automatic camera steering control and video conferencing

Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.

Cellular analysis using Raman surface scanning

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San Jose, CA, United States of America

Andrew A Berlin