Advanced Neuromodulation Systems, Inc.

Other

Functional Neuromodulation, Inc.

Functional Neuroscience, Inc.

General Electric Company

University Health Network

Medtronic, Inc.

Ge Precision Healthcare LLC

The Rockefeller University

Thomas Jefferson University

Neurologix Research, Inc.

Ge Intellectual Property Licensing, LLC

Andres M Lozano

Helen S Mayberg

Alexandre Boutet

Suresh Emmanuel Joel

Radhika Madhavan

Marcos Velasco

Hiroki Toda

Francisco Velasco

Fiacro Jimenez

Matthew J During

Mark Turner Rise

Jeffrey Michael Ashe

Thomas Kwok-Fah Foo

Ileana Hancu

Desmond Teck Beng Yeo

Michael G Kaplitt

John Karigiannis

Tracy L Cameron

Afis Ajala

Jianwei Qiu

Jurgen Germann

Gavin Elias

A system for optimizing DBS parameters for a subject includes automatically performing actions via a processor. The actions include obtaining functional MRI data of a brain of the subject acquired utilizing an MRI system during DBS of the brain utilizing a first set of DBS parameters. The actions include generating functional MRI response maps from the functional MRI data. The actions include extracting, utilizing an unsupervised autoencoder-based neural network, features from the functional MRI response maps. The actions include determining, utilizing a deep learning-based DBS parameter classification model, whether the first set of DBS parameters are optimal DBS parameters for the subject based on the features. The actions include, when the first set of DBS parameters are not the optimal DBS parameters, predicting, utilizing a deep learning-based DBS parameter prediction model, a second set of DBS parameters that are the optimal DBS parameters for the subject based on the features.

Deep learning-based automated parameter optimization and therapy system for deep brain stimulation

A system and method for identifying a patient-specific neurosurgery target location is provided. The system receives brain imaging data for a patient that includes tracts and networks in the patient brain, accesses a quantitative connectome atlas comprising population-based, disease-specific structural and functional connectivity maps comprising a pattern of tracts and networks associated with an optimal target area (OTA) identified from a population of patients, and defines the patient-specific neurosurgery target location based on a comparison between a pattern of the tracts and networks from the brain imaging data for the patient and the pattern of tracts and networks associated with the OTA identified from the population of patients in the quantitative connectome atlas. The quantitative connectome atlas comprises a disease-specific, population-based quantitative connectome atlas that identifies an optimal target location for treatment associated with a maximal clinical improvement for each disease in the population of patients.

Brain connectivity atlas for personalized functional neurosurgery targeting and brain stimulation programming

A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.

Systems and methods for predicting optimal deep brain stimulation parameters

Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

Inducing neurogenesis within a human brain

The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat an affective disorder, such as depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Method of treating depression, mood disorders and anxiety disorders using neuromodulation

Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.

Regulation of neurotrophins

The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

In one embodiment, a method of treating an eating disorder in a patient, comprises: diagnosing the eating disorder in the patient; and electrically stimulating a subgenual cingulate cortex site or a ventral medial prefrontal cortex site in the patient using electrodes of an implanted stimulation lead.

Deep brain stimulation of the subcallosal cingulate area for treatment of refractory anorexia nervosa

Methods of treating auditory hallucinations, hyperacusis, schizophrenia, and/or phonophobia include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a cochlear nucleus, auditory striae, superior olivary complex, lateral lemniscus, inferior colliculus, brachium of the inferior colliculus, medial geniculate body, primary auditory cortex, secondary auditory cortical area, and auditory radiation. Systems for treating auditory hallucinations, hyperacusis, schizophrenia, and/or phonophobia include an implanted stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a cochlear nucleus, auditory striae, superior olivary complex, lateral lemniscus, inferior colliculus, brachium of the inferior colliculus, medial geniculate body, primary auditory cortex, secondary auditory cortical area, and auditory radiation.

Stimulation methods and systems for treating an auditory dysfunction

A method for the treatment of eating disorders by nerve tissue stimulation and infusion techniques to one or more areas of the brain affecting hunger and satiety; palatability and aversion; hedonism; reward/addiction behavior; mood; anxiety; depression, taste and smell. The invention also comprises methods for the treatment of disorders of these individual behaviors and in particular, disorders of taste and/or smell.

Method for treating eating disorders

The present invention relates to a method of identifying a region of the brain by measuring neuronal firing and/or local field potentials by recording discharges from at least one implanted electrode and analyzing the recording of the discharges within the beta frequency band range to determine an area of beta oscillatory activity. Once the region of the brain is identified, this region may be stimulated to disrupt the beta oscillatory activity thereby treating a movement disorder.

Identifying areas of the brain by examining the neuronal signals

Methods and apparatus for inducing neurogenesis within a human. An implantable signal generator is used to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

Growing community of inventors

Toronto, Canada

Andres M Lozano