Twist Bioscience Corporation

Glimmerglass Networks, Inc.

Applied Materials, Inc.

Complete Genomics, Inc.

Andres Fernandez

Pierre F Indermuhle

Bill James Peck

William Banyai

Siyuan Chen

Eugene P Marsh

Bryan P Staker

Marian Mankos

Steven Thomas Coyle

Lawrence Muray

David Stern

Jeffrey S Sullivan

Xiaolan Chen

Tai-Hon Philip Chang

Windsor Owens

James Spallas

Radoje Drmanac

Kim Yang Lee

David T Amm

Timothy N Thomas

Paul C Allen

Ming Lun Yu

Douglas Earl Holmgren

William C Dickson

Shaunak Roy

Mark A Gesley

Douglas L Teeter

Allan L Sagle

Norman Lee Burns

Jay Willis Shafto

Alexander P Kindwall

Claudia Richter

Tim Thomas

Windsor E Owens

Methods and devices are provided herein for surfaces for de novo nucleic acid synthesis which provide for low error rates. In addition, methods and devices are provided herein for increased nucleic acid mass yield resulting from de novo nucleic acid synthesis.

Methods and devices for de novo oligonucleic acid assembly

Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.

Devices and methods for oligonucleic acid library synthesis

De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

De novo synthesized gene libraries

Compositions, devices, methods and systems are provided for differential functionalization of a surface of a structure to support biopolymer synthesis. Provided herein are processes which include use of lamps, lasers, and/or microcontact printing to add functional groups to surfaces for the efficient and uniform synthesis of oligonucleic acids.

Functionalized surfaces and preparation thereof

Growing community of inventors

San Francisco, CA, United States of America

Andres Fernandez