Genego, Inc.

Van Andel Research Institute

Camelot UK Bidco Limited

Thomson Reuters (scientific) Inc.

Andrej Bugrim

Tatiana Nikolskaya

Aleksander Markov

Yuri Nikolsky

Hassan Malik

Craig P Webb

Mans A Olof-Ors

Evgeny Kirtlov

Mark Gordon

Colin Williams

Igor Gariev

Tim Miller

Systems and method for making intelligent business development and licensing decisions are disclosed. The present invention generally relates to an analytical tool that combines multiple data and content sets based on user selected factors and presents the data in the form of manipulatable visualizations to facilitate decision making to address a specific business problem. More specifically, this invention relates to providing a single portal for access to a decision support system that enables the visualization of data from multiple content and data sets to facilitate decision making related to opportunities analysis, asset acquisition, and intellectual property licensing.

Methods and systems for business development and licensing and competitive intelligence

The present invention relates generally to groups of genes that can be used to diagnose and differentiate between types of specific diseases such as breast cancer. The groups of genes can be further used to develop diagnostic kits for the specific diseases. The diagnostic kits can also differentiate between sub-categories of a disease to help identify the appropriate treatment regimen for a patient.

Methods for functional analysis of high-throughput experimental data and gene groups identified therefrom

The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational 'skeletons' for integrating various types of 'high throughput' data. The present invention provides the first metabolic reconstruction study of a eukaryotic organism based solely on expressed sequence tag (EST) data.

System reconstruction: integrative analysis of biological data

The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational skeletons for integrating various types of high-throughput data. The present invention provides the first metabolic reconstruction study of a eukaryotic organism based solely on expressed sequence tag (EST) data. System Reconstruction also provides a method for the identification of novel therapeutic targets and biomarkers using network analysis. The initial seed networks are built from the lists of novel targets for diseases with the high-throughput experimental data being superimposed on the seed networks to identify specific targets.

Methods for identification of novel protein drug targets and biomarkers utilizing functional networks

The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational 'skeletons' for integrating various types of 'high throughput' data.

Methods for identifying compounds for treating disease states

A system and method for performing a research and analysis in the bioinformatics field which associates data from a variety of experimental platforms with preclinical and/or clinical samples and subjects. The system and method allows for the analysis of data stored therein received from a variety of experimental platforms, as well as association with preclinical and clinical sources. A fully integrated medical informatics/molecular bioinformatics database/analysis package is provided herein suitable for accelerated target discovery, diagnosis, and treatments for molecular-based diseases. An identified relationship is used with a computational distribution for scoring nodes in a network built from a set of experimentally-derived condition-specific genomic or proteomic profiles for the development of new treatments, diagnoses, biomarker identification, or target identification. The biomedical research tool provides for multi-directional data directionality that allows for detailed genotype to phenotype analysis for the evaluation of new drugs and treatments.

Growing community of inventors

St. Joseph, MI, United States of America

Andrej Bugrim