The Children's Hospital of Philadelphia

Johns Hopkins University

University of Pennsylvania

Andrei Thomas-Tikhonenko

Erik A Wentzel

Joshua T Mendell

Michael Dews

Asal Homayouni

James Psathas

Sisi Zheng

Elaine Chung

Elena Sotillo-Pineiro

The present disclosure is directed to antibodies binding to CD22-Del.ex5-6 protein and methods of using such antibodies to treat cancers that express or overexpress CD22-Del.ex5-6 protein. Specifically, the disclosure provides a method of treating cancer comprising contacting a cancer cell in a subject with an antibody or antibody derivative that binds selectively to CD22-Del.ex5-6 protein, or to a peptide having the sequence of QLNVKHPPKKVTTVIQNP (SEQ ID NO: 1).

Antibodies for the diagnosis and treatment of B-cell acute lymphoblastic leukemia

Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.

Compositions and methods for treating B-lymphoid malignancies

Compositions and methods useful for the treatment of cancer, particularly lymphoma, are disclosed.

Compositions and methods for transient up-regulation of Myc in B-cell lymphomas for enhancing P53 independent apoptotic responses to chemotherapy

The invention generally features compositions and methods that are useful for modulating angiogenesis.

Compositions and methods for modulating angiogenesis

Growing community of inventors

Philadelphia, PA, United States of America

Andrei Thomas-Tikhonenko