Bristol-myers Squibb Compnay

Karo Bio Ab

Andrei Sanin

Johan Malm

Pratik Devasthale

Minsheng Zhang

Denis E Ryono

Jon J Hangeland

Arthur M P Doweyko

Todd J Friends

Tamara Dejneka

Yolanda V Caringal

Peter Brandt

Konrad Koehler

Sandra Gordon

Karin Edvinsson

A method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a Tregulated gene, wherein a compound as described in the general formula I below is administered in a therapeutically effective amount: 

Thyroid receptor ligands

Thyroid receptor ligands are provided which have the general formula I wherein:   In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a Tregulated gene, wherein a compound as described above is administered in a therapeutically effective amount.

This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.

Prime ring substituted thyroid receptor antagonists for the treatment of cardiac and metabolic disorders

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Bålsta, Sweden

Andrei Sanin