Georgia Tech Research Corporation

Opencell Technologies, Inc.

Andrei G Fedorov

F Levent Degertekin

Fahrettin Levent Degertekin

John Mark Meacham

Peter Arthur Kottke

Craig Green

Yogendra Kumar Joshi

David M Anderson

David L Damm

Mark Varaday

Mason Chilmonczyk

Konrad Rykaczewski

Kiranmai Durvasula

Akash Mehta

Shannon Yee

Seung Woo Lee

Alexander Limia

In some embodiments according to the present disclosure, methods for mitigating particle retention are provided including the use of frequency sweep excitation to eject particle in the sweep. In some embodiments according to the present disclosure, the acoustically driven fluid ejector can be capable of being switched between multiple modes of operation. In other embodiments according to the present disclosure, the acoustically driven fluid ejector can be altered such that it includes the capability to be filled with a biocompatible material to aid in the mitigation of particle aggregation in the acoustically driven fluid ejector. In some embodiments according to the present disclosure, the solid structure and number of nozzles of the acoustically driven fluid ejector can be adjusted such that the ejector of the acoustically driven fluid ejector can be self-pumping, i.e. no external pumping mechanism other than acoustics driven flow drag is used.

Systems and methods for mitigating particle aggregation caused by standing wave and transient acoustophoretic effects

The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor.

Analysis system and methods of use thereof

Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.

Specimen imaging systems and methods

Embodiments of the present disclosure provide for methods and systems for making structures using an electrospray system while under vacuum. In particular, embodiments of the present disclosure provide for methods and systems for ultra-fast growth of high aspect ratio nano/meso/micro-structures with three dimensional topological complexity and control of phase and composition of the structure formed.

Systems and methods of electron beam induced processing

The present disclosure provides compositions including method of producing H, variable volume reactors, methods of using variable volume reactors, and the like.

Reactor for steam reforming and methods of use thereof

Embodiments of the present disclosure provide for a self-pumping structure, methods of self-pumping, and the like.

Self-pumping structures and methods of using self-pumping structures

Capillary trap-vapor pumps, systems, methods of heat management, and the like, are disclosed.

Evaporation cooling devices and systems and methods of removing heat from hot spots

The present disclosure provides compositions including thermo-electro-chemical converter, methods of converting thermal energy into electrical energy, and the like. In general, embodiments of the present disclosure can be used to convert thermal energy into electrical energy by way of a chemical process.

Thermo-electro-chemical converters and methods of use thereof

Thermal ground planes, thermal ground plane structures, and methods of thermal energy management, are disclosed. Embodiments of the disclosure provide for thermal ground planes and/or thermal ground plane structures for both fully passive and active two-phase heat spreaders, as well as the cooling devices and thermal management methods enabled by these planes and/or structures that enable heat dissipation from one or more high heat flux domains followed by spreading the heat laterally over a large area achieving essentially the spatially isothermal plane, structure, system, or device.

Thermal ground planes, thermal ground plane structures, and methods of heat management

Embodiments of the present disclosure provide a multistage procedure for treatment of biological samples (e.g., living cells with membranes, and the like) with a substance (e.g., a drug, DNA, RNA, plasmids, and other biomolecules or materials) to achieve more efficacious intracellular delivery and transfection.

Intracellular delivery and transfection methods and devices

Reactors and methods that generate hydrogen from fuel, such as naturally-occurring or synthesized hydrocarbon fuel. One embodiment of the reactor comprises a CO/Hactive membrane piston disposed inside a cylinder that provides for highly efficient and scalable hydrogen generation from hydrocarbon fuels. This embodiment may function in a two or four stroke modes. Another embodiment of the reactor comprises a dual piston configuration having COand Hactive membrane pistons inside a single cylinder. Other embodiments of the reactor comprise flexible membranes or diaphragms that operate in a manner similar to pistons with or without regeneration of residual reaction products. Exemplary methods introduce fuel into a controllable volume, selectively control pressure, temperature and residence time of the fuel within the controllable volume, chemically react the fuel within the controllable volume with one or more catalysts to produce one or more chemical species, selectively remove via a membrane one or more of the chemical species from the controllable volume, and exhaust residual products from the controllable volume.

Growing community of inventors

Atlanta, GA, United States of America

Andrei G Fedorov