Pain Therapeutics, Inc.

Other

Pharmacia & Upjohn Company

Pain Therapeutic, Inc.

Andrei Blasko

Nan-Horng Lin

Lindsay Burns Barbier

Hoau-Yan Wang

De-Hwa Chou

Cherng-Chyi Fu

Su Il Yum

Michael S Zamloot

Michael A Mauragis

Cherng-chyi Fu

Qingwu Jin

Qun Lu

Brenda S Vonderwell

Dian Song

De-Hwa Chao

Michael Anthony Mauragis

Brenda Sue Vonderwell

Michael Anthony Pfizer Global R & D Mauragis

Brenda Sue Pfizer Global R & D Vonderwell

A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within. 

Filamin a binding anti-inflammatory and analgesic

Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10&#x3bc; or less than or equal to 20&#x3bc; are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

Micronized opioid compositions having a specific particle size distribution

A compound or its pharmaceutically acceptable salt, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within. 

Filamin A binding anti-inflammatory and analgesic

A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within. 

Filamin A-binding anti-inflammatory analgesic

The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.

Salts and polymorphs of a pyrrole-substituted indolinone compound

Growing community of inventors

San Bruno, CA, United States of America

Andrei Blasko