University of Georgia Research Foundation, Inc.

Andrei A Poloukhtine

Geert-Jan Boons

Margaretha Wolfert

Vladimir V Popik

Jason John Locklin

Sara V Orski

Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a 'click' reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.

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Scottsdale, AZ, United States of America

Andrei A Poloukhtine