Aventis Pharma S.a.

Rhone-poulenc Rorer S.a.

Andrees Bohme

Arielle Genevois-Borella

Gaetan Touyer

Serge Mignani

Jean-Luc Malleron

Michel Evers

Jean Bouquerel

Youssef El-Ahmad

Gilles Doerflinger

Jean-Francois Sabuco

Assunta Imperato

Corrine Terrier

Marie-Christine Dubroeucq

Claude Guyon

Franco Manfre

Jidong Zhang

Yannick Benedetti

Alain Boireau

Christopher Henderson

Thierry Canton

Walter Fratta

The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH, ORc, SRc, SORa, SORa, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSORa, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF, CHF, CHF, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl, to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.

Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them

The present invention relates to the novel derivatives of formula (I) in which  A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH, ORc, SRc, SORa, SORa, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSORa, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF, CHF, CHF, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl, to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.

The invention relates to triazine derivatives of general formula (I): Wherein R, Rand Rare as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof.

Triazine derivatives, their preparation and therapeutic application thereof

The present invention relates to the combination of riluzole and of gabapentin or one of their pharmaceutically acceptable salts and its use as a medicament which is useful in particular for the prevention and/or treatment of motoneuron diseases.

Combination of riluzole and of gabapentin and its use as a medicament

A method for the prevention or treatment of cerebellar dysfunction, particularly cerebellar ataxia, by the use of riluzole or a pharmaceutically acceptable salt thereof.

Use of 2-amino-6-trifluoromethoxybenzothiazole for the prevention or treatment of cerebellar dysfunction

Heterocyclic carboxamide compounds effective in the treatment of drug

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Paris, France

Andrees Bohme