Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Institut National De La Sante Et De La Recherche Medicale

Andreas Zimmer

Raphael Mechoulam

Itai A Bab

Esther Shohami

Jorg Kreuter

Christian Noe

Marie-Christine De Vernejoul

Serap Atmaca-Abdel Aziz

Frank Stieneker

Meliha Karsak

Hans-Peter Zobel

Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.

Methods compositions and articles of manufacture for modulating bone growth

The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.

Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of acrylic acid or acrylic acid ester or methacrylic acid esters. The carrier further includes oxygen in the ester group, a branched or unbranched alkyl chain with 2-10 carbon atoms, --NR.sub.2 where R represents H and lower alkyl chains in any combination, and H or a lower alkyl chain. The grain size distribution of the carrier is 10-1000 nm.

Medicament in particulate form

Growing community of inventors

Bonn, Germany

Andreas Zimmer