Firefly Bioworks, Inc.

Cyclica Inc.

Andreas Windemuth

Daniel Colin Pregibon

Isaac Stoner

Timothy Erps

Davide M Marini

Stephen Scott Mackinnon

Jessica Dawn Tytell

Graeme Doran

Andrew Edward Brereton

Sana Alwash

Joseph Christian Campbell Somody

Daniel Pregibon

A method for predicting a property of a sample molecule involves, for each of a multitude of reference molecules, obtaining a multitude of fingerprints and at least one property, and obtaining the multitude of fingerprints of the sample molecule. The method further involves for each of the multitude of reference molecules, using each of the multitude of fingerprints, calculating distances to the sample molecule, and for each of the multitude of reference molecules, determining a relative predictive dominance, based on the distances to the sample molecule. The method also involves, for each of the multitude of reference molecules, determining a fitness value based on the relative predictive dominance, and predicting the at least one property of the sample molecule based on the at least one property of the multitude of reference molecules and the fitness values obtained for the reference molecules.

Method and system for predicting properties of chemical structures

The present invention provides, among other things, methods, compositions and systems for highly efficient, robust, multiplex analysis of biomolecules based on substrate-mediated compartmentalization in conjunction with controlled release of assay reagents for interference-free detection of biomolecules.

Substrate-mediated reactors for bioassays

The present invention provides, among other things, methods and systems for characterizing multifunctional objects using a flow-through device, such as, a flow cytometer. In some embodiments, an inventive method according to the present invention includes one more steps of (a) interrogating a plurality of objects (e.g., particles), wherein each individual object (e.g., particle) comprises one or more interrogation regions detectable as a sequence of events; (b) recording multiple events, wherein each individual event corresponds to each individual interrogation region detectable above a pre-determined triggering threshold; (c) grouping the recorded multiple events, and (d) characterizing the plurality of objects based on the grouped events.

Scanning multifunctional particles

The present invention provides, among other things, methods and compositions for encoding a substrate for detecting and quantifying target nucleic acids.

Nucleic acid detection and quantification by post-hybridization labeling and universal encoding

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Belmont, MA, United States of America

Andreas Windemuth