Thermo Finnigan LLC

Thermo Fisher Scientific (bremen) Gmbh

Andreas Wieghaus

Oliver Lange

Alexander Alekseevich Makarov

Alexander Kholomeev

Jan-Peter Hauschild

Stevan Roy Horning

John E P Syka

Robert Malek

Ulf Froehlich

Ulf Fröhlich

A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.

Method and apparatus for mass analysis utilizing ion charge feedback

A method of generating a mass spectrum from an FTMS is disclosed. A first quantity of ions from a source, having a first m/z range, is captured and detected in the FTMS measurement cell to produce a first output. A second quantity of ions, having a second m/z range which at least partially does not overlap with the first m/z range, is then captured and detected so as to produce a second output. The two outputs are then combined using a processor so as to 'stitch' together the outputs, which may be FTMS transients or may first be Fourier Transformed into the frequency mass domain, into a composite output from which a composite mass spectrum covering the full range of m/z ratios included by the first and second ranges can be produced.

Fourier transform mass spectrometer and method for generating a mass spectrum therefrom

Method and apparatus of controlling an ion population to be analyzed in a mass analyzer. Ions are accumulated for an injection time interval determined as a function of an ion accumulation rate and a predetermined desired population of ions. The accumulation rate represents a flow rate of ions from a source of ions into an ion accumulator. Ions derived from the accumulated ions are introduced into the mass analyzer for analysis.

Controlling ion populations in a mass analyzer

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Bremen, Germany

Andreas Wieghaus