University Of Zürich

Biogen International Neuroscience Gmbh

Biogen Idec International Neuroscience Gmbh

Andreas Weihofen

Jan Grimm

Roger Nitsch

Christoph Hock

Paul H Weinreb

Lihe Su

Provided are novel human &#x3b1;-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for &#x3b1;-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for &#x3b1;-synuclein targeted immunotherapy and diagnosis, respectively.

Human anti-alpha-synuclein antibodies

Provided are anti-human &#x3b1;-synuclein-specific binding molecules, e.g., antibodies or antiben-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human &#x3b1;-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human &#x3b1;-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for &#x3b1;-synuclein targeted immunotherapy and diagnosis, respectively.

Anti-alpha synuclein binding molecules

Provided are human alpha-synuclein-specific autoantibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for &#x3b1;-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for &#x3b1;-synuclein targeted immunotherapy and diagnosis, respectively.

Provided are anti-human &#x3b1;-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human &#x3b1;-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human &#x3b1;-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for &#x3b1;-synuclein targeted immunotherapy and diagnosis, respectively.

Growing community of inventors

Belmont, MA, United States of America

Andreas Weihofen