Universitat Basel

Universitaet Basel

Andreas Steck

Beat Ernst

Ruben Herrendorff

Fan Yang

Hélène Pfister

Giulio Navarra

The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone. 

Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein

The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as: whereinRis Z or whereinRis H, SOH, or whereinRis H or whereinRis H or whereinRand Rare independently H or whereinRis H or and compounds of formula (II) are defined as: whereinRis Z or whereinRis Z or wherein Z is &#x2014;N(R)&#x2014;A&#x2014;B&#x2014;CH&#x2014;(CH)&#x2014;SH, whereinRis H, C-C-alky, C-Calkoxy, CHCH, CHCHCH, OCHCH, or OCHCHCH;A is C-C-alkylene, C-C-alkoxy, C-C-alkyl&#x2014;(OCHCH)O&#x2014;C-C-alkyl, or C-C-alkoxy-R, wherein Ris an optionally substituted aryl or an optionally substituted heteroaryl, and wherein p is 0 to 6, preferably p is 1, 2 or 3, and further preferably p is 1;B is NHC(O), S or CH;q is 0 to 6, preferably q is 1, 2, 3 or 4, and further preferably q is 1 or 2.

Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids

The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substitutents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone. 

Growing community of inventors

Epalinges, Switzerland

Andreas Steck