Scil Technology Gmbh

Arte Corporation

Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg

Andreas Schuetz

Klaus Hellerbrand

Wolfgang Friess

Cornelius Pompe

Michael Siedler

Samuel Herberg

Seiji Shimazaki

Makoto Kakiuchi

Teruo Matsuda

Rainer Sigl

The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.

Dried reconstituted vesicle formation for pharmaceutical application

A device for sealing a vessel, in particular a cartridge () or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel () comprises at its opening end () an opening edge () and an adjoining longitudinal portion () with an evenly formed inner cross section, including a front plunger () to be positioned inside the vessel () at the longitudinal portion (), is characterized in that the front plunger () is configured to be positioned in the vessel () in a sealing state, in which the front plunger () is fully inserted in the vessel (), or in an exchange state, in which the front plunger () is inserted partly in the vessel () and partly protrudes over the opening edge () of the vessel (), wherein the front plunger () comprises sealing means that are configured to seal the inside of the vessel () against the outside when the front plunger () is positioned in the sealing state, and one or more communicating grooves () that are configured to place the inside and outside of the vessel () in communication with each other when the front plunger () is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel () is disclosed.

Device for sealing a vessel and method of manufacturing a sealed vessel

The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.

Biomaterial containing degradation stabilized polymer

The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.

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Stockdorf, Germany

Andreas Schuetz