E.i. Dupont De Nemours and Company

Andreas Schenzle

James M Odom

Mattheos Koffas

Qiong Cheng

Stephen K Picataggio

Pierre E Rouviere

Jean-Francois Tomb

Kelley C Norton

Genes have been isolated from16a sp. encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from astrain that is capable of utilizing single carbon (C1) substrates as energy sources. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.

Genes involved in isoprenoid compound production

A high growth methanotrophic bacterial strain capable of growth on a C1 carbon substrate has been isolated and characterized. The strain has the unique ability to utilize both methane and methanol as a sole carbon source and has been demonstrated to possess a functional Embden-Meyerhof carbon flux pathway. The possession of this pathway conveys an energetic advantage to the strain, making it particularly suitable as a production platform for the production of biomass from a C1 carbon source.

Production of feed using a denitrifying methanotrophic bacterial strain

High growth methanotropic bacterial strain

Genes have been isolated from Methylomonas 16 sp. encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Methylomonas strain that is capable of utilizing single carbon (C1) substrates as energy sources. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.

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Zurich, Switzerland

Andreas Schenzle