Arzneimittelwerk Dresden Gmbh

Arzneimettelwerk Dresden Gmbh

Andreas Rolfs

Gottfried Faust

Eveline Morgenstern

Aleksej Uschmajew

Alexander Knoll

Dieter Lohman

Peter Scharfenberg

Klaus Unverferth

Jurgen Liebscher

Jurger Liebscher

Ju/ Rgen Liebscher

The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles. Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents. The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations. Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.

3-aminopyrroles, methods for their synthesis and for their

A process for producing pharmacologically active 1-unsubstituted 3-aminopyrroles of the formula ##STR1## by ring transformation of a corresponding 1,2-thiazolium pyrrole in a single step, without producing harmful byproducts.

Method for producing 1-unsubstituted 3-aminopyrroles

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Berlin, Germany

Andreas Rolfs