Ge Healthcare As

Ge Healthcare Limited

Andreas Richard Meijer

Mikkel Jacob Thaning

Michael James Rishel

Torgrim Engell

Brian Christopher Bales

Imtiaz Ahmed Khan

Robert James Nairne

Graeme McRobbie

Gareth Simon Getvoldsen

Paritosh Jayant Dhawale

Khalid Hussain

Sondre Nilsen

Arne Wang Aabye

Ingvil Gausemel

Jarle Andre Haugan

Nikolai Enes

Salvatore Desena

Silalahi Sumihar

Paul Alexander Jones

Deirdre Cassidy

Concetta Valeria Gringeri

Imitiaz Ahmed Khan

The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.

Lanthanide complex formulations

The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.

Chelate compounds

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprisesF-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.

Radiotracer compositions and methods

The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.

Metal complex formulations

The present invention relates to in vivo imaging and in particular to magnetic resonance imaging (MRI). Provided by the present invention is a pharmaceutical formulation suitable for use in an MRI procedure and which offers advantages over known such formulations. A particular dose of the pharmaceutical formulation of the invention is also envisioned as well as the use of said dose in a method of in vivo imaging. This present invention provides for simultaneous administration of a liver specific agent and a second MR contrast agent that is capable of better/further enhancing the dynamic vascular phase in a patient. The method of the invention has the advantage of simplicity and patient comfort, compared to sequential injections. Furthermore, the method of the invention provides the advantage that it can enable a lower cumulative dose of contrast agents.

Combination formulation

The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.

DOTA synthesis

Manganese chelate compounds

The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation of MRI contrast agents based on Gd-DOTA.

Formulations of metal complexes

The present invention relates to manganese(II). The invention also relates to manganese(II) chelates attached to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).

Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI)

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Oslo, Norway

Andreas Richard Meijer