Basf Se Corporation

Other

Andreas Pletsch

Wolfgang Siegel

Christopher Koradin

Hartwig Schroeder

Manfred Ehresmann

Melanie Bonnekessel

Thomas Kaeding

Bernhard Hauer

Michael Breuer

Petr Kvita

Stephan Freyer

Nicole Holub

Franz Weber

Wolfgang Reichert

Burkhard Ernst

Peter Oedman

Stefanie Demming

Thomas Ulrich

Laurent Cavin

Ralf Hoock

Karin Schein-Albrecht

Hartwig SCHRÖDER

Peter ÖDman

Hartwig Schroder

Peter Odman

The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.

Production of pyripyropenes from dry biomass

The present invention relates to a process for reacting chemical compounds comprising the step of reacting a compound of formula (IV) wherein Hal is independently selected from Cl or Br, and Xis a monovalent anion, in the presence of an inorganic acid, wherein the aqueous inorganic acid has a concentration of at least about 60%, at a temperature of about 140&#xb0; C. to about 250&#xb0; C., to obtain a compound of formula (V) wherein Hal is as defined above.

Process for making 2,5-dihalogenated phenol

The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i). 

Method for preparing a pyripyropene compound

The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.

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Limburgerhof, Germany

Andreas Pletsch