Sartorius Stedim Biotech Gmbh

Andreas Pickl

Karl Pflanz

Sebastian Pruehl

Roland Leetsch

Martin Purshouse

Adam Gilbert

Florian Hebenstreit

Sebastian PRÜHL

A filtering system () includes a filtering apparatus having a filter unit for receiving liquid to be filtered, a receptacle for receiving filtered liquid, and an adapter () for coupling the filter unit to the receptacle, and also includes a base () having a cradle () for receiving the filtering apparatus and a base vacuum delivery port (). The adapter includes an adapter vacuum receiving port () coupled to the vacuum delivery port for driving the liquid through the filter and—as filtered liquid—into the receptacle. The cradle and the adapter have an interlocking mechanism () that locks the filtering apparatus to the cradle in a locking position in which the vacuum receiving port is sealingly coupled to the base vacuum delivery port. The base vacuum delivery port has a vacuum valve () constituted as a normally-closed valve automatically forced open when the filtering apparatus locks to the cradle.

Liquid filtering method and system

The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

Diatomaceous earth composition with a low endotoxin content

The present invention relates to an improved diatomaceous earth composition containing salt water. The diatomaceous earth composition according to the present invention comprises an agglomerated mixture of calcined diatomaceous earth particles, water and at least one inorganic salt, wherein the mass ratio of the calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the content of the at least one inorganic salt is equal to or more than 0.25 parts by mass based on 100 parts by mass of water. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition according to the present invention. In another aspect, the present invention relates to the use of the diatomaceous earth composition according to the present invention as an agent for precoat filtration or dynamic body feed filtration in biopharmaceutical applications.

Diatomaceous earth composition containing salt water

A filtering system () includes a filtering apparatus having a filter unit for receiving liquid to be filtered, a receptacle for receiving filtered liquid, and an adapter () for coupling the filter unit to the receptacle, and also includes a base () having a cradle () for receiving the filtering apparatus and a base vacuum delivery port (). The adapter includes an adapter vacuum receiving port () coupled to the vacuum delivery port for driving the liquid through the filter and&#x2014;as filtered liquid&#x2014;into the receptacle. The cradle and the adapter have an interlocking mechanism () that locks the filtering apparatus to the cradle in a locking position in which the vacuum receiving port is sealingly coupled to the base vacuum delivery port. The base vacuum delivery port has a vacuum valve () constituted as a normally-closed valve automatically forced open when the filtering apparatus locks to the cradle.

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Klein Schneen, Germany

Andreas Pickl