Eth Zurich

Universitât Bern

Rheinisch-westfalische Technische Hochschule Aachen

Rheinisch-westfällische Technische Hochschule Aachen

Andreas Pasch

Jean-Christophe Leroux

Mattias E Ivarsson

Stefan Farese

Bastien Castagner

Wilhelm Jahnen-Dechent

Steffen Gräber

Steffen GRÄBER

The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.

Inositol derivatives for use in pathological crystallization

The present invention relates to a method for determining the propensity of a fluid for calcification.

Method for determining the propensity for calcification

The present invention relates to a method for determining the propensity of a fluid for calcification characterized by the following steps: (i) adding a soluble calcium salt and a soluble phosphate salt to a sample of the fluid; (ii) incubating the sample at conditions allowing the formation of calciprotein particles (CPPs); and (iii) determining one or more of the following: (a) the rate of the formation of primary and/or secondary CPPs; (b) the amount of primary and/or secondary CPPs; and/or (c) the rate of the transition of primary CPPs into secondary CPPs, wherein an increase in one or more of (a), (b) and/or (c) of step (iii) indicates an increased propensity of the fluid for calcification.

Growing community of inventors

Bern, Switzerland

Andreas Pasch