Givaudan S.a.

Beiersdorf Ag

Andreas Natsch

Chao Wang

Felix Flachsmann

Roger Emter

Philip Kraft

Andreas Goeke

Fridtjof Schröder

Marie-Claude Fournie-Zaluski

Jean-Pierre Bachmann

Yue Zou

Feng Huang

Thierry Granier

Dominique Lelievre

Bernd Traupe

Samuel Derrer

Marc Liniger

Julie Charpentier

Francis Voirol

Lijun Zhou

Heike Laue

Michael Wasescha

Gonzalo Acuna

Samuel Jordi

Melanie Stang

Hans Gfeller

Nicolas Cocito Armanino

Chun Chen

Gonzalo Acuña

A compound of the formula (I) in which, independently, The compounds have the characteristic desirable odour qualities of the Damascone&#xae; molecules, but lack their disadvantageous skin sensitization effects.

Perfume ketones

The invention relates to organic compounds having the ability to reduce or suppress the onset of skin irritation induced by extraneous cause selected from the group of 2-heptylcyclopentanone, 2-ethoxynaphthalene; 2-methoxynaphthalene; 1-methoxy-4-(prop-1-enyl)benzene; 1-(cyclopropylmethyl)-4-methoxybenzene;  Furthermore the invention refers to compositions for topical application to the skin comprising them. It further relates to a method of reducing or suppressing the formation of skin irritation.

Organic compounds

A compound of formula I wherein R, R, Rand Rcan be independently selected from H or Me,n=0, 1,the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3', or in case n=1 an isolated double bond at position 3&#x2032; or 4&#x2032;,and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.

Crotonates having use in perfumery

Provided are methods to identify modulators and in particular inhibitors of body malodor formation employing peptidase enzymes, the peptidase enzymes and corresponding nucleotide sequences, expression vectors, transfected host cells, methods of forming the peptidase enzymes and methods to prevent body malodor.

Enzymatic methods and enzymes

Provided are personal care products and compositions that comprise at least one preservative compound selected from the group consisting of phenoxyethanol, 2-phenyl ethanol, phenoxypropanol, 3-phenylpropanol and benzylalcohol, in a total concentration of 0.1 to 1% (w/w); and at least one preservative enhancer compound selected from the group consisting of 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehye, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde, 3-methoxybenzaldehyde, 2, 4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3, 5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition does not contain certain classic bactericidal, fungicidal, sporicidal or preservative compounds. Further provided are methods of forming such compositions and products and the use of preservatives and preservative enhancers in such compositions and products.

Antimicrobial compositions

Compounds of the formula (I) or salts thereof, wherein Rrepresents alkyl, aryl, alkyl-aryl or aryl-alkyl, compositions containing same, and their use in counteracting human axillary malodour.

Glutamine derivatives as deodorants

There are provided personal care products and compositions that comprise at least one diol compound selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-methyl-1,3-propandiol, and 3-(2-ethyl-hexyloxy)-1,2-propandiol in a total concentration of 0.1% to 0.5% (w/w); and at least one preservative enhancer compound selected from the group consisting of benzaldehyde, 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde and 3-methoxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition optionally contains at least one compound selected from the group consisting of phenoxyethanol, 2-phenylethanol, and benzylalcohol, in a total concentration of 0.05 to 0.3% (w/w), but does not contain other classic bactericidal, fungicidal, sporicidal or preservative compounds. The invention is further directed to methods of forming such compositions and products and the use of preservatives and preservative enhancers in such compositions and products.

Compositions

Provided are methods to identify modulators and in particular inhibitors of body malodour formation employing peptidase enzymes, the peptidase enzymes and corresponding nucleotide sequences, expression vectors, transfected host cells, methods of forming the peptidase enzymes and methods to prevent body malodour.

Ester compounds of the formula I-a wherein Ris selected from OH, NHand NHX, wherein X is an inorganic anion, wherein Ris a singly-branched saturated or unsaturated aliphatic hydrocarbon moiety selected from C-C, wherein Ris selected from H, and a linear saturated or unsaturated aliphatic hydrocarbon moiety selected from C-C, and wherein Rand Rtogether have a total of 7 to 15 carbon atoms; that are useful as antibacterial or antifungal compounds in consumer products.

Anti-bacterial compounds

Inhibitors of axillary malodour having the formula wherein R has the same meaning as given in the specification.

Phosphinic acid analogs of glutamate

Malodour formation reducing compounds alpha-N-(3-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, alpha-N-(2-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, and alpha-N-(2,4-Dimethyl-4-phenylbutanoxycarbonyl)-L-glutamine, and their salts, compositions comprising such compounds, including cosmetic products, personal care products, and deodorant products, and methods forming such products and their use. The compounds are useful to reduce the formation of human malodour resulting from bacterial degradation of compounds naturally present in sweat, in particular axilliary malodour.

Compounds and use to reduce the formation of malodour

Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having the general formula (I) 

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Uetikon, Switzerland

Andreas Natsch