Icad, Inc.

Bayer Schering Pharma Ag

Andreas Muehler

Naira Muradyan

Hanns Joachim Weinmann

Ruediger Lawaczeck

A method for performing a high-resolution pharmacokinetic analysis for calculation of tissue parameters for a fast-enhancing tissue enables medical personnel to accurately determine pharmacokinetic parameters in fast-enhancing tissues. The method includes obtaining mask image data of the tissue when it is in a steady state condition, obtaining a time series of image data of the tissue when the contrast agent is flowing in the tissue, and increasing a spatial resolution of the time series of image data using the mask image data to obtain a time series of increased spatial resolution image data. The method further includes performing a pharmacokinetic analysis to obtain data including at least one parameter that characterizes the tissue, providing a multi-parameter look-up table derived from a combination of two or more parameters, and providing a display including one parameter or a parametric image, where the parametric image is derived from the look-up table.

Method for tracking of contrast enhancement pattern for pharmacokinetic and parametric analysis in fast-enhancing tissues using high-resolution MRI

A method, system and computer-readable medium of filtering noise pixels and other extraneous data, including saturated fat tissue and air data in image data is provided. Examples of image data may include but are not limited to magnetic resonance imaging data and computed tomography data. The method includes receiving pixel count for each signal intensity value of the image data; determining a signal intensity value, I, corresponding to a pixel count of a greatest number of pixels, N; setting a noise threshold at a signal intensity value, I, corresponding to a pixel count, N, such that Nis determined based on N; and filtering from the image data one or more pixels with signal intensity values below the noise threshold. Nmay be determined such that N=N/3 or close to N/3.

Automated methods for pre-selection of voxels and implementation of pharmacokinetic and parametric analysis for dynamic contrast enhanced MRI and CT

To increase the contrast in the imaging in an object under examination that contains at least one radiopaque element, an arrangement that has the following features is used: a) at least one essentially polychromatic x-ray radiation source that emits x-ray radiation, b) at least one energy-dispersive detector, with which the intensity of the x-ray radiation that gets through the object under examination is detectable, c) at least one correlation unit, with which the intensity of the detected x-ray radiation from a pixel of the object under examination with a first energy Ecan be correlated with the intensity of the detected x-ray radiation from the same pixel with a second energy E, d) at least one output unit for visualizing the object under examination from the pixel signals that are obtained by correlation of the intensities.

X-ray arrangement and x-ray contrast process for imaging an object under examination that contains at least one radiopaque element as well as use of the x-ray arrangement

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Mountain Lakes, NJ, United States of America

Andreas Muehler