Affiris Ag

Andreas Mairhofer

Guenther Staffler

Walter G Schmidt

Frank Mattner

Achim Schneeberger

Markus Mandler

Sylvia Brunner

Gergana Galabova

Claudia Juno

Gabriele Winsauer

Arne Von Bonin

Andrea Dolischka

Martina Lutterova

Günther Staffler

Petra Lührs

Gunther Staffler

The present invention relates to a vaccine capable to induce production of antibodies directed to PCSK9 in vivo.

Peptide vaccines against PCSK9

Disclosed is a method for detecting aSyn-specific antibodies in a biological sample, comprising the following steps: &#x2014;contacting the sample with aSyn-comprising-aggregates and allowing the aSyn-specific antibodies to bind to the aSyn-comprising-aggregates, and &#x2014;detecting the aSyn-specific antibodies bound to the aSyn-comprising-aggregates by a single particle detection technique, preferably by fluorescence activated cell sorting (FACS).

Method for detecting aSyn-specific antibodies in a biological sample

Disclosed is a method for diagnosing Alzheimer's disease (AD) wherein A&#x3b2;-specific antibodies in a biological sample of a person that is suspected of having AD are detected comprising the following steps: &#x2014;contacting the sample with A&#x3b2;-aggregates or with particles having A&#x3b2;-aggregate like surfaces and allowing the A&#x3b2;-specific antibodies to bind to the A&#x3b2;-aggregates, and &#x2014;detecting the A&#x3b2;-specific antibodies bound to the A&#x3b2;-aggregates by a single particle detection technique, preferably by fluorescence activated cell sorting (FACS); and wherein the amount of A&#x3b2;-specific antibodies detected is compared with the amount in a sample of known AD status.

Method for diagnosing alzheimer's disease (AD)

Vaccine comprising a peptide bound to a pharmaceutically acceptable carrier, said peptide having the amino acid sequence 

Vaccine

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Vienna, Austria

Andreas Mairhofer