Smithkline Beecham Corporation

Other

Andreas Kremer

Patrick Camilleri

Simon Quentyn John Rice

Jan Bernard Frederik Nicolaas Engberts

Matthew Leigh Fielden

Anthony John Kirby

The use of carbohydrate-based surfactant compounds having the general formula (I):wherein Yand Y, which may be the same or different, are carbohydrate groups; New carbohydrate-based surfactant compounds are also disclosed.

Polyhydroxy diamine surfactants and their use in gene transfer

Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.

Compounds

New peptide-based Gemini compounds comprising two linked chains (a) each having: (1) a positively charged hydrophilic head, Q or Q formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R or R , the central sections of each chain being linked together by bridge Y through residues in P and P , are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo.

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Leverkusen, Germany

Andreas Kremer