Stockhausen Gmbh & Co Kg

Andreas Klotz

Marcel Veeger

Bernd Nauels

Volker Rosenberger

Beatrice Haeusler

Karin Faensen

Gerda Maehse

Beatrice Bruecher

Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99 or proteolipid protein (PLP) 40&#x2013;60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed EAE induced in susceptible SJL/J (H-2s) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151. YFAK 50-mer having a molar ratio of about y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone&#xae;. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2s) mice with the encephalitogenic epitope PLP 139-151. Copolymers YFK, VYAK and tryptophan-containing VWAK were efficacious in alleviating severity and duration of symptoms of EAE induced by MBP 85-99, in a humanized mouse model expressing genes for both an HLA-DR-2 linked to multiple sclerosis (MS) in humans and for a T cell receptor from an MS patient.

Skin and hair care agents

The present invention relates to an agent for cleansing the skin, containing a liquid natural and/or synthetic water-based latex emulsion excluding styrene-butadiene latices, exclusively at least one organic solvent which has a lower volatility than ethanol and a boiling point >78.32&deg; C., and water.

Skin cleansing agent

The present invention relates to a skin application agent containing a polyisoprene latex.

Skin application agents

The invention relates to hydrous liquid paste or cream-like hand cleansing agents without organic solvents, especially a course hand cleanser with a rubbing agent. Said cleansing agents are characterized by a content of 10 to 30 wt. % of at least one vegetable oil from the group of triglycerides, saturated and/or unsaturated fatty acids, of 10 to 30 wt % of a tenside comprised of a fatty alcohol ethoxylate, at least one fatty alcohol ether sulfate and/or a salt of a sulfonated fatty acid, 10 to 65 wt. % water, each referring to the composition of the cleansing agent, and optionally 1 to 30 wt. % of at least one abrasive. In addition, the hand cleanser optionally contains at least one viscosity building agent and optional additional cosmetic auxiliary, accessory and/or active agents.

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Grevenbroich, Germany

Andreas Klotz