Helmholtz-zentrum Fur Infektionsforschung Gmbh

Henkel Ag & Company, Kgaa

Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie E.v. -hans-knöll-institut- (hki)

Andreas Kirschning

Rolf Müller

Heinrich Steinmetz

Rolf Wolfgang Hartmann

Klaus Gerth

Hans-Martin Dahse

Jennifer Herrmann

Kathrin Mohr

Mostafa Hamed

Sascha Baumann

Liang Liang Wang

Walid A M Elgaher

Carsten Friese

Maria Moreno

Franziska Gille

Ritesh Raju

Stephan Hüttel

Ludovic Coutable

Markus Nett

Sascha Volkan Ceylan

Walid A Elgaher

Jürgen Wichelhaus

Irene Wagner-Döbler

Stephan Huettel

Chengzhang Fu

Jannik Donner

Michael Reck

Sebastian Schieferdecker

Jonas Ammermann

Walid A M Elhaher

Frank Surup

Konrad Viehrig

Michael Wolling

Sascha Volhan Ceylan

Stephan Huttel

Chemical compounds are provided that are useful in the treatment of diseases associated with an activity of a 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzyme in pathological eukaryotic cells. In particular, compounds that exhibit inhibitory activity upon 5,10-methylenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase enzymes and their use in the treatment of cancer and/or parasitic diseases are provided.

Carolacton and derivatives thereof for use in the treatment of cell proliferation disorders

The present invention provides cystobactamides of formula (I): R&#x2014;Ar-L-Ar-L-Ar-L-Ar-L-Ar&#x2014;Rand the use thereof for the treatment or prophylaxis of bacterial infections.

Crystobactamides

The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.R&#x2014;Ar-L-Ar-L-Ar-L-Ar-L-Ar&#x2014;R&#x2003;&#x2003;(I):

Cystobactamides

The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula. 

The invention relates to a method for carrying out a chemical reaction for producing a target compound by heating in a reactor a reaction medium containing at least one first reactant, such that a chemical bond inside the first reactant or between the first and a second reactant is formed or modified. The reaction medium is brought into contact with a solid heating medium that can be warmed by electromagnetic induction and that is inside the reactor and is surrounded by the reaction medium. Said heating medium is heated by electromagnetic induction with the aid of an inductor and the target bond is formed from the first reactant or from the first and a second reactant and said target bond is separated from the heating medium.

Method for carrying out chemical reactions with the aid of an inductively heated heating medium

The invention relates to a method for carrying out an oxidation reaction for producing a product by heating a reaction medium containing a reactant and oxygen or an oxygen carrier in a reactor, wherein the reaction medium is brought into contact with a solid heating medium which may be heated by electromagnetic induction, which is surrounded by the reaction medium. The heating medium is heated by electromagnetic induction using an inductor, wherein an oxidation reaction is carried out on the first reactant to give a product and the product is separated from the heating medium. The inductor preferably generates an alternating field with a frequency in the range 1 to 100 kHz, preferably in the range 10 to 80 kHz and in particular up to 50 kHz.

Method for carrying out oxidation reactions using inductively heated heating medium

The present invention relates to a method for producing cyanoacrylic acid esters. The method is based substantially on a transesterification reaction, wherein the transesterification reaction is performed in the presence of at least one transition metal catalyst that is formed by reacting at least one hydroxyl group-containing support material with at least one transition metal alkoxide.

Method for producing cyanoacrylate esters in the presence of transition metal catalysts

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Celle, Germany

Andreas Kirschning