Molecular Devices (austria) Gmbh

Molecular Devices Corporation

Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Ctr Carinthian Tech Research Ag

Metrohm Ag

Silicon Austria Labs Gmbh

Andreas Kenda

Josef J Atzler

Harald Schenk

Andreas Tortschanoff

Werner Scherf

Marin Kraft

Oksana Sirenko

Felix Spira

Martin Verhoef

Gerald AUBÖCK

Thomas Gisler

Martin Kraft

Methods, systems, and apparatus for cultivating cells in media-exchanging wells. In an exemplary method of cell cultivation, a device () may be selected that includes a row of wells (), and a first reservoir () and a second reservoir () located at opposite ends of the row of wells (). Each well () may have a lower portion and an upper portion. The lower portion of each well () of at least two of the wells () may contain a cell culture in contact with a liquid. Liquid may be transferred between the first reservoir () and the second reservoir () at least partly along a flow path () defined by the device and extending through the upper portion of each well () of the row of wells (), such that molecules of the media are exchanged between or among the at least two wells ().

Method and system for cultivating cells in media-exchanging wells

The present disclosure provides a system, including methods and apparatus, for culturing, monitoring, and/or analyzing organoids. In an exemplary method of organoid culture, the method may comprise disposing a scaffold in a receptacle having an open side. A sealing member may be bonded to the open side of the receptacle to create a chamber. An organoid may be formed in the chamber using the scaffold. Fluid and/or at least one substance may be introduced into the chamber from an overlying reservoir for contact with the organoid.

System and method for organoid culture

Incubation system and method for automated cell culture and/or testing. An exemplary incubation system may comprise a housing forming a chamber. A rack may define storage positions to support an array of sample holders inside the chamber. A detection robot may be configured to capture one or more images of cells contained by one or more wells of each sample holder while the sample holder remains at one of the storage positions of the rack. A fluid handling station may be configured to add fluid to, and/or remove fluid from, one or more wells of each of the sample holders inside the housing. At least one plate robot may be configured to move sample holders between the rack and the fluid handling station. A computer may control operation of the detection robot, the fluid handling station, and the at least one plate robot.

Incubation system and method for automated cell culture and testing

A light-field microscope includes a light-sheet focusing device configured for outputting illumination light as a light sheet, and a microlens array between an objective lens and a light detector. A sample is irradiated by the light sheet along a direction non-parallel to the sample plane. Light-field data may be acquired from the sample without needing to scan through the thickness of the sample. The microscope implements light-field acquisition in conjunction with selective plane illumination.

Light-field microscope with selective-plane illumination

An arrangement for building a compact Fourier transform interferometer for optical radiation according to the Michelson principle or a principle derived therefrom. According to the invention, this arrangement is characterized in that the optical modulation of the radiation in at least one of the interferometer arms is produced by the translational displacement of micromechanical translation mirrors that are optically accessible on one side or on both sides, with an effective oscillation amplitude of at least 50 &#x3bc;m and a usable mirror surface area of at least 1 mm. In doing so, the micromechanical mirror components according to the invention assume the function of known movable mirrors so that by using an almost massless microcomponent in comparison to conventional systems, a much smaller size and a mirror modulation frequency that is several orders of magnitude higher can be achieved. The arrangement according to the invention is used especially for optical spectroscopy.

Arrangement for building a miniaturized fourier transform interferometer for optical radiation according to the michelson principle or a principle derived therefrom

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Klagenfurt, Austria

Andreas Kenda