Siemens Aktiengesellschaft

Siemens Automotive Corporation

Continental Automotive Gmbh

Mannesmann Aktiengesellschaft

Other

Siemens Aktiengesell Schaft

Noliac A/s

Kappel, Andreas

Gottlieb, Bernhard

Wallenhauer, Carsten

Schwebel, Tim

Andreas Kappel

Bernhard Gottlieb

Bernhard Fischer

Randolf Mock

Hans Meixner

Tim Schwebel

Enrico Ulivieri

Carsten Wallenhauer

Georg Bachmaier

Robert Wolfgang Kissel

Heinrich-Jochen Blume

Karl-Heinz Mittenbühler

Jack R Lorraine

Andreas Keller

Eckart Meese

Petra Leidinger

Christina Backes

Cord Friedrich Stähler

Eric Chemisky

Christian Tump

Franz Dirauf

Donal Medlar

Jingming Jim Shen

Roland Keller

Björn Werner

Markus Dehler

Rudolf Probst

Edward-James Hayes

Joachim Heinzl

Juan Manuel Roldan Gomez

The invention relates to novel miRNA markers useful for diagnosis or therapy of disease, in particular for neuronal disorders such as Alzheimer's Disease (AD).

MiRNAs as diagnostic markers

The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.

Diagnostic miRNA profiles in multiple sclerosis

The invention relates to methods for diagnosing Alzheimer's Disease (AD) with miRNA markers. Diagnosis of AD Towards the identification of biomarkers for diagnosis of AD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

Diagnostic miRNA markers for Alzheimer

A microstepper motor which comprises two electromechanical drive elements, especially piezoelectric bending actuators, having effective directions that are perpendicular to each other. These actuators act upon a drive ring to thereby rotate a shaft. The actuators are non-radially hinged to the drive ring via an approximately square shear-flexible and torsion-proof frame structure, the drive ring being arranged inside said frame. The drive according to the invention is compact, the frame and the drive ring being configured as a single injection-molded drive module.

Electromechanical motor especially a piezoelectric microstepper motor

A motor which includes two drive elements, especially piezoelectric bending actuators, having effective directions that are perpendicular to each other. These actuators act upon a drive ring to thereby rotate a shaft. Diagonally opposite securing elements are provided on the drive ring and are used to flexibly suspend the drive ring via respective articulated corner elements on respective fixing elements that are diagonally opposite the respective securing elements. The drive according to the invention is compact, having actuators that are non-radially hinged to the drive ring.

Electromechanical motor, especially a piezoelectric microstepper drive

A solid state actuator arrangement comprising an actuator which is configured as a solid state bending actuator and which has a first and a second end section opposite each other, a fastening device for fastening the first end section of the actuator in such a manner that it can still be adjusted, and connections for applying a driver signal to the actuator for adjusting the second end section by bending the actuator between at least two positions, an extension element being fastened to the free second end section of the actuator.

Solid state bending actuator comprising an extension element

A microstepper motor which comprises two electromechanical drive elements, especially piezoelectric bending actuators, having effective directions that are perpendicular to each other. These actuators act upon a drive ring to thereby rotate a shaft. The actuators are non-radially hinged to the drive ring via a torsion-proof, nested frame-type complex structure (drive module) including an interior drive ring, a frame and a U-shaped outer frame. The drive is compact and, the drive module is configured as a single injection-molded structure.

Multi-leaf collimators have a guide frame () with a plurality of metal plates () arranged in a displaceable fashion, by which each individual metal plate can be displaced by an electric motor (M), with the electric motor (M) being a rotary electromechanical motor (M), which operates according to the form-fit principle, with electromechanical actuators.

Multi-leaf collimators and operating method

An information converter has at least two material layers having polygonal base surfaces, which are connected to each other in a shear-rigid way, wherein at least in one material layer a change of length can be induced. The polygonal base surface has at least two different interior angles.

Information processor and method for the production thereof

A metering device has an actuating unit within a housing in which an actuator is inserted and a hydraulic compensating element. The hydraulic compensating element is connected to the actuator and can be filled with a fluid when subjected to pressure. A first end of the actuator is provided with a first end cap. The metering device further has a stop that is disposed on the housing in the form of a seat, faces the first end cap, and defines a stopping position for the first end cap. The stop maintains a maximum distance between a sealing element and the end cap, the distance being smaller than the actuator traveling distance such that the actuator stroke beyond the end cap is sufficient for opening the valve. The first end cap hits the stop when moving in the direction of the hydraulic compensating element such that the movement is blocked.

Metering device

A motor which includes two drive elements, especially piezoelectric bending actuators, having effective directions that are perpendicular to each other. These actuators act upon a drive ring to thereby rotate a shaft. Two tension-compression bars, which are parallel to an effective direction, are connected to the drive ring, have respective joints at their ends and are connected to the ends of a diagonal bar, relative to which the ring can be displaced in the other effective direction. The diagonal bar itself can be displaced relative to fixing elements to an effective direction via a diagonal suspension. The drive is compact, having actuators that are non-radially hinged to the ring.

A solid-state actuator drive apparatus has&#x2014;a shaft, &#x2014;a pivot bearing for supporting the shaft, &#x2014;a drive body, &#x2014;at least two actuators for the excitation of the drive body and the shaft relative to each other for causing the shaft to rotate relative to the drive body, and&#x2014;a base element, on which these components are attached. Either the drive body is configured such that it has a drive body opening, and the shaft at least leads into the drive body opening, &#x2014;or the shaft is configured as a hollow shaft, and an element of the drive body having an annular or discoid circumference is disposed therein. The drive body is disposed stationary relative to the base element. The shaft is disposed in the pivot bearing and is adjustably disposed in the radial direction of the shaft relative to the base element by the solid-state actuators.

Solid-state actuator drive apparatus

An injection valve for injecting fuel comprises a valve housing () inside of which a drive unit () controls the movement of a valve needle () that is pretensioned by a spring (). The injection valve also comprises a main chamber (), which is provided inside the valve housing, is filled with fuel and accommodates the valve needle (), and comprises a hydraulic bearing for the drive unit (). The hydraulic bearing has a hydraulic chamber () that is connected to the main chamber (), whereby fuel serves as the operating substance of the hydraulic bearing.

Injection valve

A device for controlling a capacitive charge, in particular a piezoelectric actuator () has a signal generator () which is used to control a first end step () which is used to produce a discrete signal on the capacitive charge. Device has a second end step () which is used to generate a continuous signal on the capacitive charge. A counter-coupling of a deviation of an actual discrete signal is produced by a continuous signal required on the capacitive charge.

Hybrid control circuit

The invention relates to an injection valve which has a piezo actuator that is functionally connected to a nozzle needle by a hydraulic transmission device. The hydraulic transmission device is connected to a pressure reservoir by a sealing gap so that the pressure differences between the pressure reservoir and a hydraulic chamber of the hydraulic transmission device are compensated in the long term.

Growing community of inventors

Brunnthal, Germany

Andreas Kappel