Government of the United States of America, as Represented by the Secretary of Commerce

Andreas Jahn

Michael Gaitan

Laurie E Locascio

Wyatt N Vreeland

Joseph E Reiner

Methods for the formation of liposomes that encapsulate reagents in a continuous 2-phase flow microfluidic network with precision control of size, for example, from 100 nm to 300 nm, by manipulation of liquid flow rates are described. By creating a solvent-aqueous interfacial region in a microfluidic format that is homogenous and controllable on the length scale of a liposome, fine control of liposome size and polydispersity can be achieved.

Controlled vesicle self-assembly in continuous two phase flow microfluidic channels

An apparatus to create a homogenous liposome population without post-processing using laminar flow/diffusive mixing, and for reducing waste discharge of the therapeutic or compound to be encapsulated and delivered by the liposomes.

Growing community of inventors

Gaithersburg, MD, United States of America

Andreas Jahn