Qiagen Gmbh

Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus

Diagen Institut Fur Molekular-Biologische, Diagnostik Gmbh

Analyticon Gesellschaft Fur Chemische Analytik Und Consulting Gmbh

Andreas Immelmann

Karsten Henco

Helga Rubsamen-Waigmann

Hagen Von Briesen

Ursula Dietrich

Herbert Kuhnel

Michalina Adamski

Lutz Muller-Kuhrt

HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.

HIV-2 virus variants

The invention relates to novel .gamma.-pyrones, .gamma.-pyridones and .gamma.-thiopyrones and their use as medicaments against viral diseases, preferably for the treatment of retroviral diseases, comprising compounds of the formula (I), in which R.sub.1 and R.sub.2 stand for hydrogen, a branched-chain or unbranched-chain C.sub.1 to C.sub.26, preferably C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.26 alkenyl or C.sub.1 to C.sub.26 alkinyl group or combinations thereof; R.sub.3 stands for a branched-chain or unbranched-chain C.sub.1 to C.sub.26 alkyl group; and R.sub.4 stands for a C.sub.3 to C.sub.26 cycloalkyl, branched-chain or unbranched-chain alkyl, alkenyl or alkinyl group. The hydrogen atoms of the methylenic group in R.sub.1, R.sub.2 and R.sub.4 may be substituted by O alkyl (C.sub.1 to C.sub.6), O acyl, O aryl, O aralkyl and alkyl (C.sub.1 to C.sub.6) groups, and in R.sub.4 also by halogenated groups, oxo groups and hydroxylic groups with double links. The elements represented by Z are independently from each other O, S or NH. ##STR1##

.gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, their use

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Dusseldorf, Germany

Andreas Immelmann