University of Miami

Biorep Technologies, Inc.

Zakease Surgical, Inc.

Other

Andreas G Tzakis

Ramon E Poo

Daniel Sadowski

James Morelli

Camillo D Ricordi

Antonio Pinna

An anastomosis device includes a stapler and an anvil. The stapler includes a clamp head with opposing first and second clamp jaws and a clamp actuator and clamp lock. Staple magazines are connected to the clamp jaws for retaining a plurality of staples in an array, and drivers are provided for moving the plurality of staples in the array out of the staple magazine. An anvil includes a clamp head with opposing first and second clamp jaws, a clamp actuator and a clamp lock. Anvil portions are connected to the clamp jaws. The stapler detachably engages to the anvil, and aligns the staple magazines with the anvils. The drivers are operated to move the staples from the staple magazines into contact with the anvil portions. A method for performing anastomosis is also disclosed.

Linear anastomosis clamp and stapler

A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.

Anastomosis system and method

A stapling apparatus for performing anastomosis on hollow organs which includes an adjacent aligned pair of stapling jaws for respectively retaining hollow organ ends together in aligned registration for stapling the ends together to form an anastomosis. Each of the stapling jaws has opposing hinged hemostat jaws operable for clamping respective hollow organ ends therebetween prior to stapling. The hemostat jaws include a stapling mechanism for stapling the retained hollow organ ends together.

Stapling apparatus for performing anastomosis on hollow organs

A stapling apparatus for performing anastomosis on hollow organs. The apparatus consists of two combinable tools which are L-shaped, one tool for retaining staple retaining clips, and the other tool for retaining staples. The L-shaped tools are each provided with an elongated handle and a C-shaped jaw positioned at a distal bottom end of the handle in a plane substantially transverse to the handles of the tools. When the two tools are combined, the C-shaped jaw retaining a series of staple retaining clips is positioned below the C-shaped jaw retaining the arranged series of staples with the respective staples in registration with respective underlying clips for stapling. The C-shaped jaws provide gaps which permit ingress and egress of hollow organ ends to be stapled. A staple firing mechanism is operated from the proximal top end of one of the handles of the stapling apparatus whereby downward pressures is applied uniformly and simultaneously against the top of all staples to force them from their retaining sockets, through the hollow organ ends, and into stapling engagement with the respective underlying staple retaining clips.

A novel method using anti-interleukin 2 receptor monoclonal antibodies for treating patients having severe viral hepatitis C is described. The inventive method may be used to treat recurrent hepatitis C following liver transplantation, thereby reducing complications in recipients of liver allografts.

Treatment of hepatitis C by administration of anti-IL-2 receptor monoclonal antibody

An anastomosis fastening technique wherein an annular fastener securing anvil is positioned over the end portion of a first hollow body organ to be joined to a second hollow body organ end or side portion and this first organ end is everted outwardly back over the anvil thereby forming a cuff. The anvil is provided with prepositioned and annularly disposed fastener securing devices on the exterior surface. The second hollow body organ and/or side portion is then positioned over the cuff of the first hollow body organ such that the intimal portions thereof to be anastomosed are in intimal coaptation. An anastomotic surgical fastener driving instrument with fastener cartridges therein, and which conforms in shape to the outer annular contours of the anvil is coaxially applied over the anvil with the organ portions positioned therebetween and the fastener driving instrument is then actuated to fasten the coaptating organ portions together. The organ portions to be anastomosed may first be tied down to the anvil. The fastener driving instrument is also keyed to the anvil for proper positioning of the fasteners relative to the anvil fastener securing devices prior to actuating the fastener driving instrument. The fasteners may be in the form of surgical staples, nails or tacks.

Growing community of inventors

Miami, FL, United States of America

Andreas G Tzakis