Novartis Ag

Andreas Floersheimer

Pascal Furet

Guido Bold

Andrea Vaupel

Paul William Manley

Giorgio Caravatti

Vito Guagnano

Gottfried Sedelmeier

Hans-Georg Capraro

Keiichi Masuya

Joseph Schoepfer

Carole Pissot Soldermann

Lukas Oberer

Ernst Kuesters

Eugen Boss

Donatienne Denni-Dischert

The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases. 

Bicyclic amides as kinase inhibitors

The invention relates to novel compounds of Formula I: wherein

Cyclic diaryl ureas suitable as tyrosine kinase inhibitors

The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; Ris unsubstituted or substituted phenyl; and Ris unsubstituted or substituted aryl or heteroaryl; or a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the Flt-3 kinase. 

Thiazole and pyrazole derivatives as Flt-3 kinase inhibitors

The invention relates to the use of diaryl urea derivatives in the treatment of protein kinase dependent diseases or for the manufacture of pharmaceutical compositions for use in the treatment of said diseases, methods of use of diaryl urea derivatives in the treatment of said diseases, pharmaceutical preparations comprising diaryl urea derivatives for the treatment of said diseases, diaryl urea derivatives for use in the treatment of said diseases, novel diaryl urea derivatives, pharmaceutical preparations comprising these novel diaryl urea derivatives, processes for the manufacture of the novel diaryl urea derivatives, the use or methods of use of the novel diaryl urea derivatives as mentioned above, and/or these novel diaryl urea derivatives for use in the treatment of the animal or human body.

Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases

The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation.

Epothilone derivatives

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Dornach, Switzerland

Andreas Floersheimer