Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

Hitachi High-Tech Corporation

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Andreas Finke

Michaela Windfuhr

Bernhard Hauptmann

Takeshi Ishida

Herbert Von Der Eltz

Taku Sakazume

Johann Karl

Yoshihiro Yamashita

Rupert Herrmann

Uwe Kobold

Peter Sluka

Ursula Klause

Hisashi Yabutani

Wolfgang Jona

Johannes Stoeckel

Federic Donie

Doris Renauer

An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container. The third electric power switch is opened when an amount of the reagent within the shared reagent storage container is equal to or smaller than a constant value. When one of the first electric power switch, the second electric power switch, and the third electric power switch is opened, supply of the electric power to the ultraviolet LED is intercepted.

Analyzer

The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance.

Use of signal enhancing compounds in electrochemiluminescence detection

The present invention concerns a method for producing microparticles loaded with proteins which is characterized in that the microparticles are loaded in suspension under strongly alkaline conditions. The invention also concerns microparticles which can be produced using this method and their use in a binding test e.g. in an immunoassay.

Method for producing microparticles loaded with proteins

Method for the quantitative determination of glycated protein in particular haemoglobin and HbA1c, wherein the respective sample is firstly contacted with a proteolytic enzyme and subsequently a non-immunological chromatographic separation process is carried out.

Method for the quantitative determination of glycated proteins

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Penzberg, Germany

Andreas Finke