Biovotion Ag

Solianis Holding Ag

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Other

Andreas Caduff

Mark Stuart Talary

Yuri Feldman

Etienne Hirt

Hans-Joachim Krebs

Veikko Rihu

Jussi Juva

Pavel Zakharov

Alexander Puzenko

Paul Ben-Ishai

Niki Kurki

Thomas W Schrepfer

Pascal Truffer

Atte Peltola

Antti Eskeli

Gianluca Stalder

Francois Dewarrat

Saul Yedgar

Aharon Agranat

Oscar De Feo

Gregory Barshtein

Stephan Buschor

Heinz Süsstrunk

Yaroslav Ryabov

Gianlucca Stalder

Alexander Megej

Martin Müller

Daniel Huber

François Dewarrat

A system is presented for non-invasive monitoring one or more blood conditions of a media in a region of interest. The system comprises: a sensor device comprising at least one antenna sensor configured to be placed in the vicinity of the media and configured and operable to generate antenna beams of different frequencies in a frequency range of about 100 MHz to 90 GHz, receive radiation responses from the medium, and generate corresponding sensing data; and a control unit configured to receive and process said sensing data to determine a dielectric spectrum of the media indicative of dielectric response of cytoplasm containing cells (red blood cells) in the media and determine one or more blood conditions.

System and method for non-invasive monitoring of blood conditions

Medical monitoring device

The apparatus for the non-invasive glucose detection comprises an electrical detection device () for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor () or alternative perfusion sensor (), improve the accuracy of the measured result.

Device for determining the glucose level in body tissue

A parameter affecting the absorptivity or the concentration of blood in tissue is measured using a semiconductor light source () and a light detector (). The semiconductor light source () is operated at several operating conditions, at which it has different temperatures and therefore different emission spectra. In particular, the operating conditions correspond to different time intervals after switching the light source () on, while the light source () has not yet reached thermal equilibrium. This allows to perform a spectroscopic measurement using one light source only, which increases accuracy and reduces device cost.

Optical determination of blood perfusion and similar parameters

Embodiments of the present invention comprise systems and methods for noninvasion measurements of physiological properties of tissues. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.

System for noninvasive optical measurements of physiological properties in tissue

A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

Wide band field response measurement for glucose determination

A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (), which carries a ground electrode () as well as a plurality of signal electrodes (-). The gaps () between the ground electrode and the signal electrodes are filled with a solid filler material () in order to provide an even surface. Optical reflection detectors () can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate () carries electronic high-frequency components for improving signal quality.

Sensing device for body tissue properties

A sensor device comprises a sensor () to be held against the wearer's skin. The sensor () is arranged on one side of a housing (), and the housing is connected to a band () for mounting it to a body part, such as an arm or leg. Various stopper devices () are arranged on the side of the housing () and the band () that face the skin. The stopper devices improve static friction, thereby holding the housing () in place.

Wearable sensor device

A method and system for non-invasive determination of at least one condition of a living organism selected from physiological conditions and emotional states of the living organism are described. The method comprises sensing electromagnetic waves emanated from a skin portion in an extremely high frequency (EHF) band, and obtaining from the sensed electromagnetic waves at least one unique biometric signature of the living organism indicative of the organism condition. The system includes an antenna array unit configured for sensing the electromagnetic waves emanated from the skin portion; and a receiving unit configured and operable for obtaining the unique biometric signature. The sensed electromagnetic waves are indicative of bioelectric activity of neurally connected and electromagnetically interacting structures distributed in a skin portion of the living organism.

Method and system for determination of physiological conditions and emotional states of a living organism

A device for measuring the glucose level in living tissue has electrodes () for being brought into contact with the specimen and a voltage-controlled oscillator () as a signal source for generating an AC voltage in a given frequency range. The AC voltage is applied to the electrodes (). A voltage over the electrodes is fed to a processing circuitry (), which converts it to the glucose level using calibration data. The voltage-controlled oscillator () has a symmetric design with adjustable gain for generating signals in a large frequency range with low distortions at a low supply voltage. The processing circuit comprises a simple rectifier network with software-based correction. The electrodes () are of asymmetric design and optimized for biological compatibility.

Device and method for measuring a property of living tissue

A device for measuring a glucose level or some other parameter of living tissue that affects the dielectric properties of the tissue is disclosed. The device comprises an electrode arrangement () having a plurality of electrodes (-). The signal from a signal source () can be applied to the electrode arrangement via a switching assembly (). The switching assembly () is designed to selectively connect a first and a second pattern of the electrodes (-) to the signal source, thereby generating a first and a second electrical field with different spatial distribution in the tissue. By using a differential method which relies on measuring the impedance of the electrode arrangement () for each field and on suitable subtraction of the measured results, surface effects can be reduced and the focus of the measurement can be offset to a point deeper inside the tissue.

Method and device for determining a parameter of living tissue

For measuring the concentration of a substance in body fluid, such as the glucose level in blood or tissue, a strip electrode () and a ring electrode () are arranged at the specimen. The ring electrode () is in direct electrical contact with the specimen while the strip electrode () is electrically insulated therefrom. The strip electrode () is arranged parallel to an arm or a leg for obtaining a large interaction length. The electrodes () form a capacitor in a resonant circuit. A modulated voltage in the MHz range close to or at the resonance frequency is applied to the electrodes and the response of the body fluid is measured. This design allows a measurement of high accuracy.

Method and device for determining the concentration of a substance in body liquid

The device of the present invention comprises a ring () of a ferrite material and two coils () wound around it. A alternating current is fed to one of the coils (). This current gives rise to an alternating magnetic field within and along the ring, which in turn generates an alternating electric field. A specimen () is placed in the alternating electric field. The dielectric properties of the specimen () affect the electric field, which in turn induces a magnetic field and generates currents in the coils (). As the dielectric properties of the specimen () depend on its glucose level, the glucose level can therefore be measured by determining a parameter depending on the inductances of the coils.

Device for the measurement of glucose concentrations

One aspect of the invention provides a device that non-invasively determines the concentration of a substance in a target. The device includes a first electrode, a measuring circuit, and a data processor. In one embodiment of the device, the first electrode can be electrically insulated from the target, e.g., a cover layer of insulating material covers the first electrode.

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Zurich, Switzerland

Andreas Caduff