Sanofi Pasteur Sa

Ratiopharm Gmbh

Andreas Boudier

Pierre Martin

Dietmar Flubacher

Dirk Spielvogel

Markus Mueller

Ulrich Berens

Oliver Dosenbach

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: in which R'b is as defined above for (I), in which R&#x2033; is as defined in claim, and also the compounds of formula (III).

Process for preparing prophyrin derivatives, such as protoprophyrin (IX) and synthesis intermediates

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: in which R'b is as defined above for (I),and a dipyrromethane of formula (III): in which R&#x2033; is as defined in claim, and also the compounds of formula (III).

Process for preparing porphyrin derivatives, such as protoporphyrin (IX) and synthesis intermediates

The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

Synthesis methods and intermediates for the manufacture of Rizatriptan

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Basel, Switzerland

Andreas Boudier