Novartis Ag

Xenon Pharmaceuticals Inc.

Novartis Pharma Ag

Other

Sandoz Gmbh

Novartis Pharma Gmbh

Andreas Billich

Philipp Lehr

Hubert Gstach

Michael D Winther

Yigal Paul Goldberg

Erwin Paul Schreiner

Peter Ettmayer

Peter Nussbaumer

Berndt Oberhauser

Karl Baumann

Dieter Scholz

Barbara Wolff-Winiski

Ingeborg Schuster

Brigitte Charpiot

The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.

aSMase inhibitors

Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human include administering to a mammal in need thereof a compound of formula (I): 

Pyridazine derivatives and their use as therapeutic agents

The present invention relates 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C)alkyl, (C)cycloalkyl, (C)cycloalkyl(C)alkyl, (C)aryl or (C)aryl(C)alkyl and their use as pharmaceuticals.

3,4-dihydro-benzo[e][1,3]oxazin-2-ones

Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human include administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein.

3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C)cycloalkyl, (C)alkyl(C)cycloalkyl, (C)aryl or (C)aryl(C)alkyl and their use as pharmaceuticals.

MIF-inhibitors

Benzoxa- and benzthiazoles substituted at the 2 position and carrying a sulfamic acid ester group bound via oxygen to the phenyl part of the ring structure, such as the compounds of formula (I) wherein the symbols have various significances, possess interesting pharmacological activity. They can be prepared by sulfamoylation of a corresponding compound carrying a hydroxy group on the phenyl part of the ring structure, or by N-substitution. They are indicated for use as steroid sulfatase inhibitors in the prevention and treatment of illnesses responsive to steroid sulfatase inhibition, such as acne.

Benzoxa- and benzthiazoles

Chromanone and thiochromanone compounds

The invention relates to compounds of formula I ##STR1## wherein the substituents have various significances. They can be prepared by conventional methods, e.g. coupling, substitution, deprotection or protection reactions. They possess interesting pharmacological properties and are thus indicated for use in the treatment of retroviral infections, particularly as HIV proteinase inhibitors.

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Vienna, Austria

Andreas Billich