Friedrich-alexander-universitaet Erlangen-nuernberg

Asta Pharma Aktiengesellschaft

Friedrich-Alexander-Universitat Erlangen-Nürnberg

Andreas Baur

Bernhard W Fleckenstein

Gerold Schuler

Kalle Saksela

Thomas Harrer

Joachim Kalden

The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.

Method for in vitro detection and monitoring of a disease by measuring disease-associated protease activity in extracellular vesicles

Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.

Pharmaceutical compositions containing as active substance

Growing community of inventors

Erlangen, Germany

Andreas Baur