Boehringer Mannheim Italia

Boehringer Biochemia Robin S.p.a.

Beehringer Biochemia Robin S.p.a.

Andrea Zaliani

Marco Frigerio

Carmelo A Gandolfi

Carlo Riva

Sergio Tognella

Odoardo Tofanetti

Giorgio Long

Roberto D Domenico

Mauro Germini

Process for preparation of enantiomerically pure polysubstituted

Aralkyl-1,4-dihydropyridines, a method for their preparation and

Compounds of formula I ##STR1## wherein R.sub.1 is a cyano, nitro, benzoyl, acetyl, amido or alkoxycarbonyl group;

2-methylthiomethyl-dihydropyridines and pharmaceutical compositions

Compounds of formula I wherein R.sub.1 is an alkoxy carbonyl, aminocarbonyl, acetyl, benzyl, cyano or nitro group; R.sub.2 is as optionally substituted phenyl, aryl, hetaryl residue; R.sub.3 is an alkoxy-carbonyl group, X is an oxygen or sulphur atom, R.sub.4 is hydrogen, an optionally substituted alkyl, cycloalkyl, alkenyl group, Y is a single bond oxygen, sulphur or substituted nitrogen atom. Compounds of formula I are prepared by acylation from a 2-mercaptomethyl-1,4-dihydropyridine and are useful in therapy.

2-(acylthio)methyl dihydropyridines, and pharmaceutical compositions

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Milan, Italy

Andrea Zaliani