Fuisz Technologies Ltd.

Biovail Technologies Ltd.

Andrea S Blake

Robert K Yang

Richard C Fuisz

Subraman R Cherukuri

Garry L Myers

Jose F Zamudio-Tena

Paul M Croushorn

Steven E Frisbee

The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (&ldquo;bio-available&rdquo;) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

System for rendering substantially non-dissoluble bio-affecting agents bio-available

The present invention is a new mesomorphic polycrystallite product and a process for making the same. In the present invention amorphous sugar is transformed to a mesomorphic product having polycrystallites therein by a completely anhydrous process rather than by hydrating and then dehydrating the sugar. The product of the present invention is unique in shape and size, and possesses a high degree of uniformity. The properties of the polycrystallite make it possible to replace some or all of the fat in comestibles such as frostings and fillings and to provide fondants of extraordinarily fine grain.

Method of preparing mesomorphic sugar products

Mesomorphic sugar and products therefrom

The present invention is a method of entrapping an additive within carbohydrate bodies. The additive is drawn into the internal structure as a fluid during transformation of the bodies from a substantially amorphous state to a crystalline state. The present invention is also a delivery system including a carbohydrate body having an internal free volume space defined by an at least partially crystalline structure at equilibrium conditions, and an additive loaded within the carbohydrate body.

Entrapping additives in carbohydrate bodies

Growing community of inventors

Chantilly, VA, United States of America

Andrea S Blake