Eli Lilly and Company

Andrea Paula Martin

Julian Davies

Oliver Schroeder

Stuart W Bright

Karen L Cox

Chetankumar Natvarlal Patel

Joshua Dade Poorbaugh

Angus John MacDonald

Xiao-Fen Wang

Sean Edward Sissons

Fabio Magrini

Neelufar Mozaffarian

Stuart Willis Bright

Karen Leigh Cox

Angus John Macdonald

Provided are antibodies, or an antigen-binding fragment thereof, that binds human IL-21, These antibodies are useful in immunoassays of IL-21 levels, and/or in vivo, ex vivo or in vitro immunochemical and other imaging methods for determining the presence of IL-21 and/or quantifying IL-21 levels, and for diagnostic, prognostic and predictive purpose, and or optimizing therapeutic regimens in patients in which IL-21 signaling is implicated in pathogenesis.

Methods of detecting human IL-21

The invention relates to engineered, humanized antibodies that have high binding affinity for and neutralize human IL-21, methods of using the antibodies to treat conditions in which antagonism or neutralization of the effects of IL-21 is warranted, such as autoimmune conditions, compositions and methods for recombinantly producing the antibodies, and pharmaceutical compositions comprising the antibodies.

IL-21 antibodies and methods of making or using the antibodies

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Carmel, IN, United States of America

Andrea Paula Martin