University of California

Università Degli Studi Di Parma

Università Degli Studi Di Urbino "Carlo Bo"

Fondazione Istituto Italiano Di Tecnologia

Fondazione Istituto Italiano Di Technologia

Andrea Nuzzi

Tiziano Bandiera

Daniele Piomelli

Giorgio Tarzia

Marco Mor

Fabio Bertozzi

Angelo Mario Reggiani

Annalisa Fiasella

Chiara Pagliuca

Stefano Ponzano

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

Amide derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors

Carbamate derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors

Growing community of inventors

Davoli, Italy

Andrea Nuzzi